3 ms·
Makes sense. An interesting question is what causes the epigenetic modifications that drive the tumor forward. Do the driver mutations also cause these modifica
by gmarx 10y ago
Makes sense. An interesting question is what causes the epigenetic modifications that drive the tumor forward. Do the driver mutations also cause these modification? Is it random and these cells are selected for?
- epistasis 10y agoIt's also the other way around: the epigenetic state and physical conformation of the genome drives what subsequent mutations happen. Mina Bissel has been doing great work over the past 30 years showing that many breast "cancer" cell lines lose their cancer phenotype when they're in the proper 3D structures. Mutations are a key part of cancer, but they're not sufficient to be the sole drivers of carcinogenesis.
- gmarx 10y agoYou mean when the chromosomes are in their proper structures? What messes up the physical conformation of the chromosomes? Is it a combination of existing mutation and epigenitic mods? Or something else?