Given that we don't know what advances lie in the future, I just don't understand how one can say "no comparably huge changes remain", as this is equivalent to

Given that we don't know what advances lie in the future, I just don't understand how one can say "no comparably huge changes remain", as this is equivalent to a prediction about the future, and those are notoriously terrible. Future predictors always want you to ignore the hundreds of times they've previously been wrong, and just get you to focus on this one call here.