3 ms·
My guess is that the effect of the inhibitors is not linear with concentration. Imagine that the effective (deleterious) dose of these inhibitors is, say, 10%
by tominous 10y ago
My guess is that the effect of the inhibitors is not linear with concentration.
Imagine that the effective (deleterious) dose of these inhibitors is, say, 10% of the amount found in old mice. So an equal exchange between two mice is enough to provide an effective dose to the young mouse, but not enough to eliminate an effective dose to the old mouse.
- ttflee 10y agoIf this inhibitor hypothesis were true, an experiment could be set up to determine which component/combination of components in the old-blood actually plays the inhibitor role, with injection of separated part by component of old-blood into the young mice, more or less like a binary search. After knowing the exact combination, it would be much easier to target the inhibitor itself.