1. You are correct about the potential for long term damage. However the evidence I have seem indicates the permanent damage is due to neurotoxicity while the s

1. You are correct about the potential for long term damage. However the evidence I have seem indicates the permanent damage is due to neurotoxicity while the serotonin is depleted, while the serotonin depletion itself is temporary. Contrary to other posts here, the serotonin depletion can last in the order of 2 years, however, although this is usually in extreme cases. 2. When speaking about potential for abuse, it's worth making a distinction between drugs which cause dependency and/or chemical craving, and drugs that don't. You can develop habits without dependence or craving, but that can apply to almost anything, and is much less of an indicator that the thing is harmful. MDMA certainly had Prentiss for habitual use, usually as part of a multiple-drug-abuse condition, but in and of itself does not have dependence or craving properties.