This is what worked [0] for me in the last couple of projects (and the current one): - Backend: Django + Django Rest Framework + Postgres - Frontend: React +

This is what worked [0] for me in the last couple of projects (and the current one): - Backend: Django + Django Rest Framework + Postgres - Frontend: React + Redux + React Router + webpack + million other small modules [1]. You may also look into Relay (esp. upcoming v2: https://github.com/facebook/relay/issues/1369 https://github.com/facebook/relay/issues/1369) and GraphQL, because it may simplify a lot of backend <-> frontend communication. [0] as in: I am productive using these tools. Partially, because I already know the tooling and best practices. [1] yes, there's a lot to learn about the tooling, but when you're just starting, you can use some boilerplate or Create React App tool.