Very happy to have your comment, Gwern. I am a big fan of some of your work. I certainly agree with you in principle. I just am not sure the sample sizes here

Very happy to have your comment, Gwern. I am a big fan of some of your work. I certainly agree with you in principle. I just am not sure the sample sizes here are truly large enough to capture an effect on the order of 1.25x for such a complex phenotype. It's not necessarily a criticism of the author's work, which appears to be well-done. I just updated my prior and remain not yet convinced. I also agree that many psychiatric disorders certainly have integral immune components, but on the other hand this is also true for most chronic diseases and pathologic processes (in my opinion).