It's not just that. It's that big business can have economies of scale which allows it to push out each unit at a cheaper price point. This then trains consumer

It's not just that. It's that big business can have economies of scale which allows it to push out each unit at a cheaper price point. This then trains consumers to want things at certain price points which then makes it difficult or impossible to compete with larger companies. Further it is much easier for larger business to get investor money and debt financing, so if they want to expand it's much easier for them to do so than for small business. Also for B2B it's again much easier for big business because most of the spending done in the economy is by big business, and they don't care that much about price as consumers and can afford a lot more because they have lots saved up. So there are many factors that favor big business and shut out the little guy who is doing it because he wants more autonomy in his life.