Silicon Valley (or at least the large corps) is very aware of the regionalization of software adoption. Its simply that how success is defined for them is by,

Silicon Valley (or at least the large corps) is very aware of the regionalization of software adoption. Its simply that how success is defined for them is by, as you said, large numbers that often require something larger than small regions. One of the difficulties of SV is that several people have made the "Facebook for Brazil" or the "X for Y region" but over long term iteration, the regionalized product gets overtaken by a supra-regional product's momentum.