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I'm not an expert in vaccine development but I believe this could lead to a preventative treatment. Unfortunately, the treatment would probably be very dangerou
by akiselev 10y ago
I'm not an expert in vaccine development but I believe this could lead to a preventative treatment. Unfortunately, the treatment would probably be very dangerous because unlike smallpox or polio, the human body can't effectively fight HIV and an acute infection almost always turns into a chronic one. If a patient's immune system fails to attack a weakened smallpox strain (the vaccine) and it turns into an acute infection, the risk of life altering side effects is minuscule and more often than not, your immune system will fight off the infection. HIV is different because its only real effect on the body is the destruction of T-cells, which the virus uses to reproduce, and there is no stopping that process only slowing it down. If you take an HIV vaccine developed with this antibody and your immune system fails to learn it (or the strain mutates before it has a chance to, which is a remote but very real possibility with retroviruses), you will eventually develop AIDS or spend a lifetime taking expensive drug cocktails with a long list of serious side effects.
There are tricks to developing vaccines without using the pathogen directly, like constructing a decoy with the relevant surface proteins, but they're unlikely to work with HIV because it's so simple. When an antibody finds its antigen, it signals the immune system to consume the pathogen and learn about it if it hasn't seen the invader before. Since antibodies share a chemical structure (like DNA and RNA, except more complex), cells in the immune system can memorize the antibody and produce it even if it isn't present in our genetic code. This process is one of the most amazing adaptations in the animal kingdom, allowing complex organisms to compete with the microscopic in the evolutionary arms race, but the immune system needs to see the antibody and pathogen in order create mature B-cells, which adapt to bind to the same pathogen as the antibody. HIV is small, simple, and doesn't have many unique features on the viral package (which contains the RNA) so it'll likely be very hard to produce a decoy for the antibody to latch on to.