If in this case you've a /home that is an NFS mount shared across several nodes running different *nix or even Linux distros then yes, that is a problem. Cento

If in this case you've a /home that is an NFS mount shared across several nodes running different *nix or even Linux distros then yes, that is a problem. Centos6 will have different Gnome versions than Centos7. However, both will write in ~/.gnome, possibly .gtk, or .gtk-3.0 or wherever the hell they write to these days. Better to share your data through an nfs share in /data instead of /home and take the pain of not having the exact Desktop across different nodes. Or to create a homogenous environment with only Centos7 for example.