I took the original comment to be asking why bother taking out PD-1 from the T-cells. The answer is that it obviates the need for checkpoint inhibitors, which y

I took the original comment to be asking why bother taking out PD-1 from the T-cells. The answer is that it obviates the need for checkpoint inhibitors, which you would otherwise need to administer together with the CAR T-cells for best efficacy. Maybe they meant something different. Checkpoint blockade alone is a great development, but having treated patients with these drugs, I can tell you it is far from a cure for 80% of people.