I like Pylons. I've used it for both big sites (http://www.bittorrent.com/ http://www.bittorrent.com/) and small ones (http://codepad.org/ http://codepad.org/)

I like Pylons. I've used it for both big sites (http://www.bittorrent.com/ http://www.bittorrent.com/) and small ones (http://codepad.org/ http://codepad.org/), and it's been pretty good for both.