Scott Alexander ('Slate Star Codex') wrote a very good post on how to think about the "chemical imbalance theory", where it's useful and where it's not. Here it

Scott Alexander ('Slate Star Codex') wrote a very good post on how to think about the "chemical imbalance theory", where it's useful and where it's not. Here it is: http://slatestarcodex.com/2015/04/05/chemical-imbalance/ http://slatestarcodex.com/2015/04/05/chemical-imbalance/ I also remember reading another article by someone in the field which explained it in terms of proximal and distal causes, which is basically about "different level[s] of abstraction" as tbrownaw in this thread puts it. Will link to it if I manage to find it.