Maybe at high levels of play it would, but limiting the APM to even very low levels (e.g. 60 APM, i.e. 1 action per second) would still allow the computer to ma

Maybe at high levels of play it would, but limiting the APM to even very low levels (e.g. 60 APM, i.e. 1 action per second) would still allow the computer to macro very efficiently, so I don't think it would be a balanced difficulty adjustment. It would be simulating highly skilled player with limited mobility rather than a player that is overall less skilled.