And the pattern continues. C, G, D and A major are the easiest to play in because their key signature has respectively 0, 1, 2 and 3 sharps. Further, C# and F

And the pattern continues. C, G, D and A major are the easiest to play in because their key signature has respectively 0, 1, 2 and 3 sharps. Further, C# and F major are probably right behind those four because most people playing the guitar will just use a capo and play in C and E major respectively.