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But these are healthy men — they're not going to suffer any risks if they get somebody else pregnant. I don't believe what I'm reading. Give up your life as yo

But these are healthy men — they're not going to suffer any risks if they get somebody else pregnant. I don't believe what I'm reading. Give up your life as you know it or live with the guilt of "not being there", + the social and financial stigma that comes with it? No risks? You must be joking.

rgbrenner 10y ago
I read it as "health risks"... because of the context of the paragraph
- nothrabannosir 10y ago
  That must be it. You're right. Thankfully :) my mistake.
- sundvor 10y ago
  So mental health isn't health, then? I beg to differ, so the paragraph still doesn't compute.
- inimino 10y ago
  What does "but these are healthy men" have to do with it? That paragraph is just poorly worded.
  - mattkrause 10y ago
    Clinical trials typically have something called a Data and Safety Monitoring Board, which periodically reviews safety (and, occasionally efficacy) data to decide if the trial should be halted prematurely. The DSMB is supposed to consider the potential benefits to the individual subjects and the population from which they're drawn, and weigh that against possible risks from the drug and the trial (e.g., complications from biopsies). Since the subjects here are otherwise healthy men, who have other options for avoiding pregnancy, the DSMB should be fairly risk adverse and willing to kill the trial (as happened here). If, on the other hand, the trial were testing a new kind of anti-cancer therapy on patients with terminal cancer, the Board might be willing to tolerate a few more adverse events because the pay-off s are much higher. The article seems to be saying, in a ham-fisted way, that the DSMB would have tolerated slightly more risk to women because pregnancy also carries its own risks.
irb 10y ago
Plenty of men aren't there and don't feel guilty about it. And stigma? Only if you live in a very small, close-knit community. For men, unlike women, involvement is a choice. Not an easy choice, but still a choice.
- tomp 10y ago
  There are still other risks/consequences of pregnancy for men (financial). Women have a choice post-sex, men don't.
  - irb 10y ago
    Both of these things depend on what country you live in. The US, EU etc are not the world. The biological consequences, on the other hand, are certain and universal.
deleted 10y ago
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rgbrenner 10y ago

I read it as "health risks"... because of the context of the paragraph

nothrabannosir 10y ago
That must be it. You're right. Thankfully :) my mistake.
sundvor 10y ago
So mental health isn't health, then? I beg to differ, so the paragraph still doesn't compute.
inimino 10y ago
What does "but these are healthy men" have to do with it? That paragraph is just poorly worded.
- mattkrause 10y ago
  Clinical trials typically have something called a Data and Safety Monitoring Board, which periodically reviews safety (and, occasionally efficacy) data to decide if the trial should be halted prematurely. The DSMB is supposed to consider the potential benefits to the individual subjects and the population from which they're drawn, and weigh that against possible risks from the drug and the trial (e.g., complications from biopsies). Since the subjects here are otherwise healthy men, who have other options for avoiding pregnancy, the DSMB should be fairly risk adverse and willing to kill the trial (as happened here). If, on the other hand, the trial were testing a new kind of anti-cancer therapy on patients with terminal cancer, the Board might be willing to tolerate a few more adverse events because the pay-off s are much higher. The article seems to be saying, in a ham-fisted way, that the DSMB would have tolerated slightly more risk to women because pregnancy also carries its own risks.

irb 10y ago

Plenty of men aren't there and don't feel guilty about it. And stigma? Only if you live in a very small, close-knit community. For men, unlike women, involvement is a choice. Not an easy choice, but still a choice.

tomp 10y ago
There are still other risks/consequences of pregnancy for men (financial). Women have a choice post-sex, men don't.
- irb 10y ago
  Both of these things depend on what country you live in. The US, EU etc are not the world. The biological consequences, on the other hand, are certain and universal.

deleted 10y ago

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