Tobacco smoke also contains monoamine oxidase inhibiting compounds, which are believed to drastically increase the addictive potential of nicotine. Rats are lar

Tobacco smoke also contains monoamine oxidase inhibiting compounds, which are believed to drastically increase the addictive potential of nicotine. Rats are largely indifferent to nicotine alone, but will compulsively self-administer nicotine in combination with an MAOI. http://www.sciencedirect.com/science/article/pii/S0024320506004619 http://www.sciencedirect.com/science/article/pii/S0024320506... http://jneurosci.org/content/25/38/8593.long http://jneurosci.org/content/25/38/8593.long http://www.sciencedirect.com/science/article/pii/S0091305703002235 http://www.sciencedirect.com/science/article/pii/S0091305703... Cigarettes do give a more immediate and intense nicotine 'hit'. Ammonia compounds are added to cigarette tobacco, which increase the proportion of freebase nicotine to nicotine salts. Cigarettes are, in a very literal sense, the crack cocaine of nicotine delivery. http://www.ash.org.uk/files/documents/ASH_623.pdf http://www.ash.org.uk/files/documents/ASH_623.pdf