It's not so much "applications" as such, but it isn't uncommon for programs in bioinformatics to only be released as a binary (often only a Linux one) because t

It's not so much "applications" as such, but it isn't uncommon for programs in bioinformatics to only be released as a binary (often only a Linux one) because they want to reserve the right to license their code. Or they will only release the source code to academic researchers because they don't like the idea of industry benefiting from their work. This is changing with a lot of people hosting projects on Github and the like, but is still there.