Space is cheap, Land is expensive. Orbiting factories have relatively little constraint on their size. No need to worry about regulations or cleanup. You don't

Space is cheap, Land is expensive. Orbiting factories have relatively little constraint on their size. No need to worry about regulations or cleanup. You don't get hemmed in by neighboring factories. I can see a whole number of variables costing factories off of terrestrial production in the future with land cost being a major one.