If Scheme will do, Chicken, Bigloo, and Gambit all compile to C code as an intermediate step (which you then run through gcc or whatever to generate the binary)

If Scheme will do, Chicken, Bigloo, and Gambit all compile to C code as an intermediate step (which you then run through gcc or whatever to generate the binary). Bigloo will also generate JVM and .NET output (.NET is still experimental). I haven't worked much with Gambit, but have fooled around with both Chicken and Bigloo. Of the two, I found Chicken to be the friendliest (it also seems to have a somewhat more active community). Another possible advantage of Chicken is that it's directly supported by SWIG. There was some activity on the Chicken mailing list a few months back about porting some game libraries. I don't know what the current status of that might be.