Some things to look at when thinking about the plausibility of senescent cell clearance as a rejuvenation therapy. 1) 25% median life extension in mice: http:/

Some things to look at when thinking about the plausibility of senescent cell clearance as a rejuvenation therapy. 1) 25% median life extension in mice: http://dx.doi.org/10.1038/nature16932 http://dx.doi.org/10.1038/nature16932 2) Reverses aspects of lung tissue aging in mice, including loss of elasticity: http://insight.jci.org/articles/view/87732?key=a306472a4316d65a4eac http://insight.jci.org/articles/view/87732?key=a306472a4316d... 3) The missing link in diabetic retinopathy: http://dx.doi.org/10.1126/scitranslmed.aaf9440 http://dx.doi.org/10.1126/scitranslmed.aaf9440 4) A factor in atherosclerosis development: http://dx.doi.org/10.1126/science.aaf6659 http://dx.doi.org/10.1126/science.aaf6659 Which really just scratches the surface of the enormously amount of research accumulated since the 1960s on the role of senescent cells in aging and age-related diseases. The lung tissue paper above is a particularly good read if you want to get a sense for the nuts and bolts of the issue. Senescent cells secrete signals that disrupt tissue structure and cellular behavior, and even at 1% of the population, that is enough to produce pathology. But on the other hand, 1% is small enough to clear without major disruption, so targeted destruction is a very plausible technology, and removing some fraction of these cells as a one-time treatment should be all upside. Repeat as needed.