This is how I've been working for a couple of years now. The ergonomics seem pretty good since the keyboard is narrow and central. You also aren't moving off a

This is how I've been working for a couple of years now. The ergonomics seem pretty good since the keyboard is narrow and central. You also aren't moving off axis to use the touch pad. If a (desktop) eGPU over thunderbolt 3 can deliver the performance it would probably be my preferred solution long term.