An investment of fourteen hours of training over five weeks does result in some changes: Changes in Cortical Dopamine D1 Receptor Binding Associated with Cogni

An investment of fourteen hours of training over five weeks does result in some changes: Changes in Cortical Dopamine D1 Receptor Binding Associated with Cognitive Training McNab et al. Science 6 February 2009: 800-802 Working memory is a key function for human cognition, dependent on adequate dopamine neurotransmission. Here we show that the training of working memory, which improves working memory capacity, is associated with changes in the density of cortical dopamine D1 receptors. Fourteen hours of training over 5 weeks was associated with changes in both prefrontal and parietal D1 binding potential. This plasticity of the dopamine D1 receptor system demonstrates a reciprocal interplay between mental activity and brain biochemistry in vivo. http://www.klingberglab.se/pub/McNab2009.pdf http://www.klingberglab.se/pub/McNab2009.pdf