For me it was Pyramid+SqlAlchemy - For me probably best python web framework if you want something more than CMS. On frontend I think Polymer and Web Component

For me it was Pyramid+SqlAlchemy - For me probably best python web framework if you want something more than CMS. On frontend I think Polymer and Web Components are a game changer - very low entry barrier and they feel like a proper way to do web development where everything is encapsulated.