G protein-coupled receptors (GPCR) are the targets for the majority of the best-selling drugs on the market. Approximately 40-50% of pharmaceuticals target them

G protein-coupled receptors (GPCR) are the targets for the majority of the best-selling drugs on the market. Approximately 40-50% of pharmaceuticals target them in some way. There are more cannabinoid receptors than any other GPCR in our bodies. With 113 known cannabinoids, including chemicals that we produce ourselves, the potential for new and novel treatments are huge. Further understanding the mechanism by which our own endogenous cannabinoids like anandamide, or how other external cannabinoids like THC work is important. It can help us better comprehend the role CB1 and CB2 receptors play in regulating all sorts of functions like pain, mood, appetite, and more. Additionally, from the paper itself, we're highly interested as to why some synthetic cannabinoids have caused fatal, and extremely dangerous reactions, while chemicals like THC appear to have extremely high thresholds of safety (no recorded overdoses). I believe cannabis research is incredibly important. This study provides direction, and further understanding for not only what we already know, but what we may enable in the future.