Like, swap right button with left? There is an option for that in "accessibility settings" of most OSs. Left-handed people use it sometimes. BTW, two possible

Like, swap right button with left? There is an option for that in "accessibility settings" of most OSs. Left-handed people use it sometimes. BTW, two possible sources of mouse issues I know: 1. Sharp angle between palm and forearm, happens when the mouse is too low and too close to the body. Put it elsewhere. 2. Palm forced to lie horizontally, while the natural position would be angled (lay your hand comfortably on the desk and see that the palm isn't flat at all). This is solved by putting mouse on angled surface or getting mouse/trackball with angled top. See Microsoft Trackball Optical (not sold anymore) for example of what I mean.