This is a subject I know well, not only as a multi-decade prescriber of antidepressants, and many other classes of medications for health/behavioral problems.

This is a subject I know well, not only as a multi-decade prescriber of antidepressants, and many other classes of medications for health/behavioral problems. I've also been prescribed such medications for my own conditions, so you could say I have a unique perspective, know the issues coming and going. Of course antidepressants can cause side-effects as do all other types of drug treatments. It's inevitable, medication effects are extremely complex and unpredictable as interaction with body systems covers a huge gamut of possibilities. Furthermore, most effects of drugs haven't studied even when they are known and a great deal more is not known than is known. Also bear in mind that drugs in the form prescribed may not be the the chemical that produces the biggest therapeutic effect. This is the phenomenon of active metabolites which are often the drivers of favorable and unfavorable effects. So we see how quickly these factors yield immense complexity and the reason behind the fact that drugs often have a huge array of side-effects common and rare. BTW a side-effect occurring in 1% of recipients is considered a common adverse event. 0.1% is infrequent. Maybe 0.01% is getting rare, but definitely not implausibly drug-related. The bottom line is that taking several drugs even one at a time for more than a few days means there's a surprisingly high probability of have an uncommon or rare side effect. It's happened to me a handful of times, including a couple of pretty serious reactions. Interesting when I tell my physicians about these reactions. There's a certain look they get on their faces, like "what are you talking about? You're kidding me, that really didn't happen, did it?" Well, yes doctor, it really did, as though I wouldn't know a bad reaction when it's there or I just made the whole thing up. This is perfectly consistent with what patients reported to me over the years. A long time ago I'd come to believe that people weren't making stuff up, unusual side-effects are ultimately an everyday reality among patients and all reports of AEs must be taken seriously, exactly my policy I put into practice. Remember this little rule, it will save everyone a lot of trouble: any drug can cause any side-effect at any time.