4 ms·
It is impossible to tell from their website what they did. My institution does not have a subscription to "Future Medicine" so the best I can get is the abstra
by thisisnotmyname 16y ago
It is impossible to tell from their website what they did. My institution does not have a subscription to "Future Medicine" so the best I can get is the abstract.
It sounds like they've altered the expression of 3 key developmental genes (none of which are telomerase, but may be upstream of it). These genes transform the cells into an induced pluripotent stemcells (iPS). They created 6 lines, five of which showed telomere shortening to similar levels of that seen in other iPS lines. However, one of the iPS lines they created the TRF (dna that telomerase acts on) continued to lengthen for 60 days.
The flowchart picture is science fiction - they haven't done anything like that in this study.