3 ms·
There's a theory that since telomeres decrease in size every mitosis that they are the reason for the Hayflick limit (the max number of times a cell can divide)
by bshep 17y ago
There's a theory that since telomeres decrease in size every mitosis that they are the reason for the Hayflick limit (the max number of times a cell can divide). The theory then says that as cells reach the limit you 'age'.
The article says they figured out a way to increase telomeres in the lab, this is not very new though there are known telomerase inducers out there.
I'm not sure how revolutionary it is though the article has very little info and I've read about this topic since more than 10 years ago.
EDIT: Found this from 2007:
"Since 2007, several compounds have been discovered that cause somatic cells to express higher levels of telomerase than usual. In April 2007, Geron Corporation licensed New York-based company TA Sciences to conduct human trials on a molecule called TA-65, a derivative of Astragalus propinquus, that acts as telomerase activator"
-- http://www.lef.org/news/LefDailyNews.htm?NewsID=5216&Section=AGING http://www.lef.org/news/LefDailyNews.htm?NewsID=5216&Sec...
- thisisnotmyname 17y agoIt is impossible to tell from their website what they did. My institution does not have a subscription to "Future Medicine" so the best I can get is the abstract. It sounds like they've altered the expression of 3 key developmental genes (none of which are telomerase, but may be upstream of it). These genes transform the cells into an induced pluripotent stemcells (iPS). They created 6 lines, five of which showed telomere shortening to similar levels of that seen in other iPS lines. However, one of the iPS lines they created the TRF (dna that telomerase acts on) continued to lengthen for 60 days. The flowchart picture is science fiction - they haven't done anything like that in this study.