3 ms·

Have there been animal model tests of these particles?

• danielmorozoff 10y ago
  Seems so. Results are conflicting in terms of adverse effects. But seem to show these particles cross into normal cells (neurons for example)/ some lead to death some do not. here is a quote though from one paper in mice at high concentrations: 'There was no effect on other haematological parameters. Histopathological evaluation of dendrimer-treated groups did not reveal any abnormalities in the low- and medium-dose groups, but at a high dose level, toxicity was observed in the liver and kidney.' http://rspa.royalsocietypublishing.org/content/466/2117/1535 http://rspa.royalsocietypublishing.org/content/466/2117/1535 http://pubs.acs.org/doi/abs/10.1021/mp300391v http://pubs.acs.org/doi/abs/10.1021/mp300391v https://www.ncbi.nlm.nih.gov/pubmed/27534577 https://www.ncbi.nlm.nih.gov/pubmed/27534577