3 ms·

To some degree there are things that are "resistance proof", in that forming resistance to them would defacto leave organisms unable to survive in the human bod

To some degree there are things that are "resistance proof", in that forming resistance to them would defacto leave organisms unable to survive in the human body. A good example is highly acid/basic environments, thermal stress, or alcohols and solvents. Anything that can reproduce in a 50 degree C alcohol bath, for example, is going to have a tough time adapting to humans well enough to be pathogenic. These polymers might be a similar phenomenon, but that would also imply that they're inimical to humanity too, though perhaps at a higher concentration.

todd8 10y ago
Don't forget prions. They survive temperatures above 120C and also alcohol and remain infectious. (Hydrogen peroxide and alkalis seem too work, but see [1] because I really know nothing of the science of sterilization.) [1] https://www.ncbi.nlm.nih.gov/m/pubmed/21271212/ https://www.ncbi.nlm.nih.gov/m/pubmed/21271212/
- Senji 10y ago
  Prions aren't alive, by the same measure asbestos is also resistant.
  - todd8 10y ago
    Prions, like viruses, reproduce when inside a host. Parasites, bacteria, fungi, viruses and prions are all types of pathogens. Sterilization protocols need to be followed to ensure that one patients prions don't infect another surgery patient. It turns out that relatively recent concerns over transmissible spongiform encephalopathy, caused by prions, has required changes to the sterilization procedures used in hospitals.
dnautics 10y ago
the fact that the polymers don't kill the mammalian cells means that whatever mammalian cells do to avoid destruction can be adapted by bacterial cells for their survival.
- jaggederest 10y ago
  Except that there are fundamental differences between bacterial cells and mammalian cells that we can exploit which are extremely unlikely to change. For example, nearly all antibiotics and antifungals target cell walls - a clear distinction that mammalian cells lack.
  - dnautics 10y ago
    That's not true. Antifungals target ergosterol, which is a cell membrane compound (fungal cholesterol). Also the side effects are likely due to the similarities between ergosterol and cholesterol.

todd8 10y ago

Don't forget prions. They survive temperatures above 120C and also alcohol and remain infectious. (Hydrogen peroxide and alkalis seem too work, but see [1] because I really know nothing of the science of sterilization.) [1] https://www.ncbi.nlm.nih.gov/m/pubmed/21271212/ https://www.ncbi.nlm.nih.gov/m/pubmed/21271212/

Senji 10y ago
Prions aren't alive, by the same measure asbestos is also resistant.
- todd8 10y ago
  Prions, like viruses, reproduce when inside a host. Parasites, bacteria, fungi, viruses and prions are all types of pathogens. Sterilization protocols need to be followed to ensure that one patients prions don't infect another surgery patient. It turns out that relatively recent concerns over transmissible spongiform encephalopathy, caused by prions, has required changes to the sterilization procedures used in hospitals.

dnautics 10y ago

the fact that the polymers don't kill the mammalian cells means that whatever mammalian cells do to avoid destruction can be adapted by bacterial cells for their survival.

jaggederest 10y ago
Except that there are fundamental differences between bacterial cells and mammalian cells that we can exploit which are extremely unlikely to change. For example, nearly all antibiotics and antifungals target cell walls - a clear distinction that mammalian cells lack.
- dnautics 10y ago
  That's not true. Antifungals target ergosterol, which is a cell membrane compound (fungal cholesterol). Also the side effects are likely due to the similarities between ergosterol and cholesterol.