My astro CCD has a (slow) fan attached the peltier. The vibration isn't usually a big deal for two main reasons: 1) If your setup is sophisticated enough that

My astro CCD has a (slow) fan attached the peltier. The vibration isn't usually a big deal for two main reasons: 1) If your setup is sophisticated enough that fan vibration may cause an issue, you're likely already using a german-equatorial mount and some kind of guiding correction (secondary guide scope, or off-axis guider). These adjust the scope's positioning in real-time to keep on-target. So that removes any large-scale deviation that may be caused. 2a) Small-scale deviation is generally not a problem, since most setups are likely to be limited by the resolution of your entire optical train. For example, my 800mm newtonian combined with a CCD with 7.2mm pixels means I have a resolution of ~2.01 arc-seconds. Assuming perfect guiding, my scope can tolerate any vibration as long as my target stays within ~2 arc-seconds. * 2b) In reality, most locations are limited by seeing conditions (e.g. how turbulent the air is), which averages 1-3 arc-seconds in non-mountain regions. Also the calibration of your mount (periodic errors, guiding errors, etc) are almost certainly a greater concern than the vibration added from the peltier. That's from an amateur's perspective. Obviously high-end setups will start to worry about things like the fan's vibration, but for someone with a backyard setup (doubly so for someone using a consumer DSLR instead of dedicated CCD), there are bigger causes of inaccuracy :) * This is a bit of a simplification, since things get a bit more complicated due to FWHM, wavelength, etc.