Perhaps I fell well outside of the normal patient in this case but I've been taking a small-ish dose (500mg/day) for about two years for treatment of Migraine.

Perhaps I fell well outside of the normal patient in this case but I've been taking a small-ish dose (500mg/day) for about two years for treatment of Migraine. As my previous comment states, I make it a point not to read the side-effects (that's my wife's "job") and haven't noticed anything unpleasant about the medication other than it reducing my anxiety and making drinking alcohol less enjoyable. Perhaps my dose is particularly low. For the first couple of months I was at 1000mg/day and asked to have it reduced because the stark difference in going from mild-moderately anxious to zero anxiety made me not feel particularly like myself (reducing anxiety also reduced excitement and the enjoyment that came with it, so I felt a little too "leveled out") but even at that dose it was very tolerable and I would have been fine if I had to go back up to it to manage my symptoms. On the flip-side, I haven't suddenly been able to learn a foreign language (something that I calculate would require a lot of neuroplasticity for me -- I've struggled to learn any language beyond English most of my life) and my pace of learning -- which is something I'm inherently passionate about -- doesn't seem to be any better than it was two years ago. So while I wouldn't agree with the assessment of it being unpleasant and having a high incidence of side effects in my particular, anecdotal, case, I also wouldn't recommend self-medicating with it in my particular, anecdotal, case, unless, of course, you have suffered from Migraine for a couple of decades and have problems with the common medications prescribed for treatment. It's an interesting drug. When I started taking it, there was no information on WebMD/drugs.com indicating that it could be used for the prevention of Migraine. Forum posts throughout the interwebs abounded with anecdotal tales of people being surprised by the sudden elimination of symptoms. I, like them, was prescribed the medicine for a different purpose (though, in my case, I didn't have the disease it was prescribed for), but after seeing an expensive headache specialist that I had already had an appointment on the books for (made six months prior), I was told that he sometimes prescribes it for that purpose and it "either works or it doesn't" in his experience. It was a hit for me. And as of a search a few months ago, the more mainstream sites indicate that it is sometimes prescribed for Migraine. That it might have other benefits is great as far as I'm concerned, especially since I think I pay a little over a dollar for a 1-month supply.