This is interesting - I just posted a comment about being prescribed Depakote to handle Migraine (which has completely eliminated my bi-weekly attacks for the l

This is interesting - I just posted a comment about being prescribed Depakote to handle Migraine (which has completely eliminated my bi-weekly attacks for the last two years). I haven't paid particular attention to this kind of effect (and now that I know about it, I am certainly able to fall into placebo). Frankly, I haven't noticed any side effects from the medicine[0] other than a minor one of no longer enjoying the effects of alcohol -- though I was never a heavy drinker, I haven't drank at all since I started taking it because the relaxing, positive effects of a glass of wine are no longer present. [0] I've stuck to a rule about side-effects for medicines like this. My wife reads them thoroughly and I explain anything "different" that I might be feeling when taking the drug and allow her to make the judgement call as to whether or not I need to call the doctor/pharmacist. Because these medicines have such a huge list of side-effects, I'd find myself expecting to get one or more of them so much that I'd manufacturer them in nocebo effect style.