I read an amazing theory of this on reddit: https://www.reddit.com/r/Nootropics/comments/4z8znn/can_one_realistically_use_adderall_daily_for/d6udj1m https://www

I read an amazing theory of this on reddit: https://www.reddit.com/r/Nootropics/comments/4z8znn/can_one_realistically_use_adderall_daily_for/d6udj1m https://www.reddit.com/r/Nootropics/comments/4z8znn/can_one_... >As far as I know, when ADHD individuals are treated with amphetamine(s) even long-term, the dopamine D4 receptor in the prefrontal cortex does not down-regulate. This means that the pro-cognitive benefits of the amphetamines, namely executive function improvement [ability to organize thoughts, plan your day and exhibit sustained attention] are all improved. >However, what most people experience when they first start Adderall or any amphetamine is the massive surge of motivation and in particular energy. This energy can be massively addictive as it is basically anxiolytic first time around while simulteanously giving you big bouts of motivation and pro-sociability. Neuropsychopharmacologically speaking, these effects are due to dopamine D2 and D3 receptor stimulation in the nucleus accumbens (and effects in the ventral tegmental area, accounting for some of the motivating experience, most likely), however, what is important to note, is that after somewhere around 1-3 weeks, these receptors down-regulate and dose-escalation is needed to retain the pro-social, pro-energetic, pro-anxiolytic effects. >In other words, while amphetamines may be a piss poor choice of drug for sustained energy production long-term, the pro-cognitive benefits for individuals with executive function deficit (whether diagnosed ADHD, drug abuse, or traumatic brain injury) do exist in long-term. I think this is one of the reasons that some ADHD individuals are capable of staying at the same dose for a long period of time and still reap the benefits. In other words, the 'high' that drug users get from doing speed once, is very different than the effect that benefits people with ADHD. While the high tolerates over time and requires higher and higher doses, the beneficial effects don't seem to tolerate and last long term.