Brute-force search is idiotic testing, almost by definition. The smart approach is sparse matrices, optimized either by staring at mountains of data (possible c

Brute-force search is idiotic testing, almost by definition. The smart approach is sparse matrices, optimized either by staring at mountains of data (possible computer-assisted), or by gut feeling. Oftentimes the search space is so large (protein crystallization involves at least buffer, precipitant, pH, concentration) that you need to look at promising spots in the search space.