4 ms·
I don't know off the top of my head of any drugs that work in humans but have intolerable problems in mice. I do know that some substances are much more toxic t
by philipkglass 10y ago
I don't know off the top of my head of any drugs that work in humans but have intolerable problems in mice. I do know that some substances are much more toxic to other mammals than to us. For example, acetaminophen is very toxic to cats. Theobromine is much more toxic to dogs and cats than to humans. 2,3,7,8-Tetrachlorodibenzo-p-dioxin is rapidly lethal to guinea pigs at a level that might only cause skin problems and/or reproductive defects in humans.
- wyager 10y agoPermethrine is highly lethal to cold-blooded animals and cats.
- luminiferous 10y agoNot exactly a drug, but during animal testing of saccharin in the 1970s, saccharin was found to induce bladder cancer in mice in high doses. However, the mechanism of action was later found to be specific to rodents and not applicable to humans.
- blackbagboys 10y agoMinoxidil, the active ingredient in Rogaine, is lethal to cats.
- eth0up 10y agoCuriously, felines are apparently among the most resistant mammals to prions, maybe second to pigs.