5 ms·
> I would guess that you are right simply because most drugs that initially show promise in mice fail during clinical trials in humans. What about the contrapo
by beambot 10y ago
> I would guess that you are right simply because most drugs that initially show promise in mice fail during clinical trials in humans.
What about the contrapositive... How many substances fail in mouse studies (and are discarded), yet would have been viable in humans? Any known examples of this?
- philipkglass 10y agoI don't know off the top of my head of any drugs that work in humans but have intolerable problems in mice. I do know that some substances are much more toxic to other mammals than to us. For example, acetaminophen is very toxic to cats. Theobromine is much more toxic to dogs and cats than to humans. 2,3,7,8-Tetrachlorodibenzo-p-dioxin is rapidly lethal to guinea pigs at a level that might only cause skin problems and/or reproductive defects in humans.
- wyager 10y agoPermethrine is highly lethal to cold-blooded animals and cats.
- luminiferous 10y agoNot exactly a drug, but during animal testing of saccharin in the 1970s, saccharin was found to induce bladder cancer in mice in high doses. However, the mechanism of action was later found to be specific to rodents and not applicable to humans.
- blackbagboys 10y agoMinoxidil, the active ingredient in Rogaine, is lethal to cats.
- eth0up 10y agoCuriously, felines are apparently among the most resistant mammals to prions, maybe second to pigs.
- simonsarris 10y agoWell, we certainly are lucky we didn't test the drug "chocolate" on dogs first.
- scotty79 10y agohttps://en.m.wikipedia.org/wiki/Warfarin https://en.m.wikipedia.org/wiki/Warfarin Not sure if it applies though because it being severly harmful to rodents hasn't prevented us from looking into this substance closely. Quite the opposite.
- cariaso 10y agoMuch of our human testing only happened after a human attempted to use it for suicide, unsuccessfully. If anything this example helps to prove the parent's point. from your wikipedia link After an incident in 1951, where a US Army inductee unsuccessfully attempted suicide with multiple doses of warfarin in rodenticide and recovered fully after presenting to a hospital, and being treated with vitamin K (by then known as a specific antidote),[70] studies began in the use of warfarin as a therapeutic anticoagulant. It was found to be generally superior to dicoumarol, and in 1954 was approved for medical use in humans. An early recipient of warfarin was US president Dwight Eisenhower, who was prescribed the drug after having a heart attack in 1955.[70]