What large factors outweigh calorie content? There are plenty of dietary restrictions for things like Crohn's and diabetes, but they're easily worked around wit

What large factors outweigh calorie content? There are plenty of dietary restrictions for things like Crohn's and diabetes, but they're easily worked around without changing overall calorie consumption. Hypothyroidism and other metabolic diseases can't cause weight gain without an overabundance of calories consumed. The fact that someone's BMR lowers because of them is not a bigger factor than how much calories a person consumes.