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> I suspect that the Depo Provera injections at about age 20 is what turned my friend into a drug addict Have you considered that post hoc is not necessarily p

• tcj_phx 10y ago
  > Have you considered that post hoc is not necessarily proper hoc. Disruption of the endocrine glands is on the drug safety information [1]: Effects on the Hypothalmic-Pituitary-Adrenal Axis Some patients receiving medroxyprogesterone acetate may exhibit suppressed adrenal function. Medroxyprogesterone acetate may have cortisol-like glucocorticoid activity and provide negative feedback to the hypothalamus or pituitary. This may result in decreased plasma cortisol levels, decreased cortisol secretion, and low plasma ACTH levels. The use of DEPO-PROVERA Sterile Aqueous Suspension may, due to its cortisol-like glucocorticoid activity, also produce Cushingoid symptoms such as weight gain, edema/fluid retention, and facial swelling. [1] http://www.fda.gov/Safety/MedWatch/SafetyInformation/ucm232329.htm http://www.fda.gov/Safety/MedWatch/SafetyInformation/ucm2323... edit: p.s. Thanks for commenting, I'd never looked at Depo Provera's safety information before. Someone else had said that he thought that Depot-Provera's FDA approval, in spite of what's known about it, is a good example of 'Regulatory Capture'. Psychosis is associated with cortisol deficiency [2], so this safety information strongly supports my theory about the origin of my friend's mental health struggles. [2] https://www.jcu.edu.au/news/releases/2016/june/stress-hormone-link-with-psychosis https://www.jcu.edu.au/news/releases/2016/june/stress-hormon...