There is a large body of academic research on the topic. Here's a few to get you started: Emulating Emulation-Resistant Malware https://people.eecs.berkeley.ed

There is a large body of academic research on the topic. Here's a few to get you started: Emulating Emulation-Resistant Malware https://people.eecs.berkeley.edu/~dawnsong/papers/2009%20emulating%20p11-kang.pdf https://people.eecs.berkeley.edu/~dawnsong/papers/2009%20emu... Detecting Environment-Sensitive Malware http://www.syssec-project.eu/m/page-media/3/disarm-raid11.pdf http://www.syssec-project.eu/m/page-media/3/disarm-raid11.pd... Revolver: An Automated Approach to the Detection of Evasive Web-based Malware https://www.usenix.org/system/files/conference/usenixsecurity13/sec13-paper_kapravelos.pdf https://www.usenix.org/system/files/conference/usenixsecurit... MalGene: Automatic Extraction of Malware Analysis Evasion Signature: https://www.cs.ucsb.edu/~vigna/publications/2015_CCS_MalGene.pdf https://www.cs.ucsb.edu/~vigna/publications/2015_CCS_MalGene...