2 ms·
That's not the only problem. Every time phage therapy comes up, I end up posting my thoughts on it (and this is from someone who loves, and wanted to work in, p
by Fomite 10y ago
That's not the only problem. Every time phage therapy comes up, I end up posting my thoughts on it (and this is from someone who loves, and wanted to work in, phage therapeutics):
Phage therapy is neat, it really is, but there are a couple major issues:
- There is no such thing as a "broad spectrum" phage. You can't do empirical treatment using phages, and there's not really "off the shelf" phage therapy - it tends to be a bespoke creation for a particular infection.
- There's some serious regulatory problems, similar to those experienced by fecal transplant treatments. We're not yet really equipped to think about handling evolving, custom microbes as a treatment.
- Because of the first, it's going to require a considerable amount more lab capacity than most clinical settings currently have, and considerable delays until treatment.
- There's also some biosafety issues around phage prep, but those are easily solvable.
It's a great way to treat particularly resistant or hard to treat infections, but it's not a particularly great general solution. There's a reason it was abandoned in countries with easy access to antibiotics - they're just roundly superior in basically every respect.