It's absolutely a big issue. The main site of antibiotic treatment is hospitals (in the developed world) and if people come to hospital with a treatable or part

It's absolutely a big issue. The main site of antibiotic treatment is hospitals (in the developed world) and if people come to hospital with a treatable or partially treatable infection and then we treat with antibiotics of last resort, and then they aren't treatable anymore because transfection of resistant plasmids happens in hospital, that person dies