4 ms·
Gut microbiome seems to be linked to many diseases. My knowledge in biology and medicine is next to zero, but I was wondering if the following would be a feasib
by mynegation 10y ago
Gut microbiome seems to be linked to many diseases. My knowledge in biology and medicine is next to zero, but I was wondering if the following would be a feasible strategy:
* collect many samples from people with various symptoms
* do metagenomic sequencing on these samples to find what
species are present in which samples
* machine learn the s--t out of this to find associations/correlations
* ...um, profit?
What would be the main problem on this way? Cost? Reliability of sequencing? Correlation not implying causation? Me talking nonsense?
This finding, from what I understand, connected Crohn to the presense of three species working together to form a microfilm. Would not that be something to be found with the method like this?
- hanklazard 10y agoYou'd also want to analyze the genomes of each individual from which the samples were taken, particularly for immune factors. While no one has figured out exactly why specific gene variants such as HLA-b27 seem to be implicated in a number of autoimmune diseases, the associations are clearly there.