The introduction of HIV protease inhibitors in 1995-6 was pretty big. http://content.nejm.org/cgi/content/abstract/338/13/853 http://content.nejm.org/cgi/conte

The introduction of HIV protease inhibitors in 1995-6 was pretty big. http://content.nejm.org/cgi/content/abstract/338/13/853 http://content.nejm.org/cgi/content/abstract/338/13/853 > Mortality among the patients declined from 29.4 per 100 person-years in 1995 to 8.8 per 100 person-years in the second quarter of 1997.