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I've posted here before about helping my girlfriend with her substance abuse problems... Methamphetamine makes her extremely psychotic for at least 3-5 days. M

by tcj_phx 10y ago

I've posted here before about helping my girlfriend with her substance abuse problems... Methamphetamine makes her extremely psychotic for at least 3-5 days. My observation is that Cocaine is a much safer stimulant, as it only makes her "mildly psychotic" until the effects wear off, then she quickly recovers. She's complained to me that cocaine doesn't work anymore, as it doesn't create the euphoria that it used to. Methamphetamine is easier to find, I guess. My girlfriend is currently being mistreated by "professionals", who have assumed that she's "persistently disabled" because she'd been court-ordered before. They have been completely hostile to treating the underlying causes of their patient's symptoms: alcohol, prescription drugs (anti-psychotics [1] & benzodiazepines), and other substances (stimulants, mainly). [1] https://en.wikipedia.org/wiki/Substance-induced_psychosis#Other https://en.wikipedia.org/wiki/Substance-induced_psychosis#Ot... - "antipsychotics, in an idiosyncratic reaction" (emphasis added) Preliminary evidence found that Progesterone USP also helps people recover from brain injuries. A poorly designed study was hastily implemented, the ineffective method of progesterone administration was found to not help, and the Progesterone USP theory of neuroprotection is not being studied anymore.

meowface 10y ago
Sorry for your issues with the medical system, but how is this related to the article?
- lostlogin 10y ago
  Presumably the progesterone bit?
  - meowface 10y ago
    It's possible I completely missed it, but I don't remember that last paragraph being in his post when I first replied to it.
axlprose 10y ago
as someone who's prescribed amphetamine (i.e. adderall) for [inattentive] ADHD, and have also tried meth-amphetamine, I just want to point out that those are two very different drugs as far as effects and potency go. Methamphetamine is so strong, I honestly couldn't even tolerate small amounts of the stuff. The few times I've tried it just resulted in dehydration, headaches, and muscle aches, easily outweighing any cognitive effects it had (which weren't even really more noticeable than regular amphetamine's effects for me). Cocaine isn't as bad, but still a bit too much for me as well. Regular amphetamine on the other hand, the compound this article is about, has given me quite a noticeable improvement in my quality of life. Results do vary even among us adhd people, but for me, I've never experienced anything worse than staying up a bit later than I would like from taking it. Otherwise it just feels like drinking a really strong cup of tea for me, cause even coffee makes me more jittery. So the research in this article doesn't surprise me too much, but it's always nice to have some extra reassurance against all the anti-adhd-medication propaganda that originally made me paranoid about even trying it back when I was first diagnosed.
- meowface 10y ago
  Low recreational doses of dextroamphetamine also give me dehydration, headaches, and muscle aches if I'm not properly hydrated or haven't eaten in a while. So that might've played a role. Methamphetamine is proven to be more neurotoxic than amphetamine even when accounting for its extra potency, though, so it should ideally only be taken infrequently, in very low doses, or not at all. There are some neuroprotective substances you can take beforehand to mitigate the damage, but it's probably not worth it.
  - dfsegoat 10y ago
    As a general rule in pharmacology: putting a methyl- group on any molecule increases its ability to cross the blood-brain-barrier and have increased psychoactivity (and neurotoxicity): METH-amphetmaine N-METHyl-D-aspartate (NMDA) di-METHYL-tryptamine (DMT) etc
- dfsegoat 10y ago
  Same case here. Back this assessment 100%. I was prescribed desoxyn once back in the 90s -- it is methamphetamine, and my body could not handle it. The Adderall IR tablets however (30mg bid) - i have no problem with tolerating - and would venture to say that my functional life would be difficult without it - I certainly could not be a software engineer and probably would have never even finished my degree.

by tcj_phx 10y ago

meowface 10y ago

Sorry for your issues with the medical system, but how is this related to the article?

lostlogin 10y ago
Presumably the progesterone bit?
- meowface 10y ago
  It's possible I completely missed it, but I don't remember that last paragraph being in his post when I first replied to it.

axlprose 10y ago

as someone who's prescribed amphetamine (i.e. adderall) for [inattentive] ADHD, and have also tried meth-amphetamine, I just want to point out that those are two very different drugs as far as effects and potency go. Methamphetamine is so strong, I honestly couldn't even tolerate small amounts of the stuff. The few times I've tried it just resulted in dehydration, headaches, and muscle aches, easily outweighing any cognitive effects it had (which weren't even really more noticeable than regular amphetamine's effects for me). Cocaine isn't as bad, but still a bit too much for me as well. Regular amphetamine on the other hand, the compound this article is about, has given me quite a noticeable improvement in my quality of life. Results do vary even among us adhd people, but for me, I've never experienced anything worse than staying up a bit later than I would like from taking it. Otherwise it just feels like drinking a really strong cup of tea for me, cause even coffee makes me more jittery. So the research in this article doesn't surprise me too much, but it's always nice to have some extra reassurance against all the anti-adhd-medication propaganda that originally made me paranoid about even trying it back when I was first diagnosed.

meowface 10y ago
Low recreational doses of dextroamphetamine also give me dehydration, headaches, and muscle aches if I'm not properly hydrated or haven't eaten in a while. So that might've played a role. Methamphetamine is proven to be more neurotoxic than amphetamine even when accounting for its extra potency, though, so it should ideally only be taken infrequently, in very low doses, or not at all. There are some neuroprotective substances you can take beforehand to mitigate the damage, but it's probably not worth it.
- dfsegoat 10y ago
  As a general rule in pharmacology: putting a methyl- group on any molecule increases its ability to cross the blood-brain-barrier and have increased psychoactivity (and neurotoxicity): METH-amphetmaine N-METHyl-D-aspartate (NMDA) di-METHYL-tryptamine (DMT) etc
dfsegoat 10y ago
Same case here. Back this assessment 100%. I was prescribed desoxyn once back in the 90s -- it is methamphetamine, and my body could not handle it. The Adderall IR tablets however (30mg bid) - i have no problem with tolerating - and would venture to say that my functional life would be difficult without it - I certainly could not be a software engineer and probably would have never even finished my degree.