Keep in mind you still have the constraint of the Yerkes–Dodson law [0]. Drugs that are neuroprotective at therapeutic doses can easily become neurotoxic at ext

Keep in mind you still have the constraint of the Yerkes–Dodson law [0]. Drugs that are neuroprotective at therapeutic doses can easily become neurotoxic at extremely high supratherapeutic doses. The only exception that comes to mind is memantine, which leads to a clearly disassociative state, but recreational use (again supratherapeutic doses) hasn't been studied thoroughly. [0] https://en.wikipedia.org/wiki/Yerkes%E2%80%93Dodson_law https://en.wikipedia.org/wiki/Yerkes%E2%80%93Dodson_law