A lot of the meta around NT has to do with knowing what weapons work well across stages of the game and are complementary, then balancing ammo requirements with

A lot of the meta around NT has to do with knowing what weapons work well across stages of the game and are complementary, then balancing ammo requirements with the need to dish out spike damage. If you haven't made it past the sewer that you've probably seen < 15% of the game. I've particularly found melee weapons(wrench) particularly good at dealing with the sewers.