Yes, they will mix sprites at different resolutions. Ron has stated multiple times that it is possible to enable a "true" low resolution mode, to the point wher

Yes, they will mix sprites at different resolutions. Ron has stated multiple times that it is possible to enable a "true" low resolution mode, to the point where he'll get quite grumpy if you bring it up on the comments. He's also said that he thinks it is tinted (or tainted) by nostalgia and not something you'd actually want to use for more than a few seconds just to try it out. They have explicitly said that they're not going for an adventure game in the truly old style, but for something that feels like it is.