I've used a number of different email clients, but I think that the simplest tools, if applied properly, should solve this problem. Trouble is, though, is that'

I've used a number of different email clients, but I think that the simplest tools, if applied properly, should solve this problem. Trouble is, though, is that's really specific to what mail you get. When someone un-CCs themselves from a bug report, find something that's common to every subject line (or better yet, the sending address, since it's probably your tracking software's server), and make a filter for that. Also, I think most clients allow you to distinguish between mails just to you and mass emails. I would just make a folder for every category you can think of, set up the filters as best you can, and then prioritize the categories. Emails that are written solely to you and don't look like notifications you get on a regular basis are probably the most important. Then replies, etc...